반응 #47881

반응 방정식

(4-{4-[5-(6-hydroxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

compound A3

(4-{4-[5-(6-hydroxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

NaH

2-bromoethylmethylether

→

solid

수율 52.0%

[4-(4-{5-[6-(2-Methoxy-ethoxy)-naphthalen-2-yl]-pyrazolo[1,5-c]pyrimidin-7-ylamino}-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester

수율 52.0%

용매

DMF

반응 조건

후처리

1. 1
   추출after extraction the crude product
2. 2
   기타is purified by silica gel flash chromatography

실험 절차

To a solution of (4-{4-[5-(6-hydroxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester (compound A3)(120 mg) in DMF (3 ml) are added NaH (8 mg) and 2-bromoethylmethylether (0.019 ml). The mixture is stirred overnight and after extraction the crude product is purified by silica gel flash chromatography. A nearly colorless solid (68 mg) in 52% yield is obtained.

출처