반응 #47843

반응 방정식

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

benzylamine

sodium iodide

→

titled compound

수율 44.0%

1-benzylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

수율 44.0%

용매

THF

반응 조건

후처리

1. 1
   온도by refluxing for 6 hrs
2. 2
   세척The resulting mixture washed with saturated saline
3. 3
   추출extracted with ethyl acetate
4. 4
   기타The organic layer was separated
5. 5
   건조dried over anhydrous MgSO4
6. 6
   농축concentrated under a reduced pressure
7. 7
   기타The resulting residue was purified by flash chromatography

실험 절차

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (120 mg, 0.32 mmol) obtained in Example 18 was dissolved in THF (10 mL), and benzylamine (102.87 mg, 0.11 mL, 0.93 mmol) and sodium iodide (9.60 mg, 0.06 mmol) were added thereto, followed by refluxing for 6 hrs. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 56 mg of the titled compound (yield: 44%).

출처