반응 #47841

반응 방정식

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethylamine

→

titled compound

수율 75.6%

1-ethylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

수율 75.6%

용매

THF

THF

반응 조건

후처리

1. 1
   기타the solvent was removed under a reduced pressure
2. 2
   기타The resulting residue was purified by flash chromatography

실험 절차

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and 2.0 M ethylamine (0.68 mL, 1.35 mmol) in THF was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 68 mg of the titled compound (yield: 75.6%).

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