반응 #47826

반응 방정식

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

수율 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

수율 52.0%

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타The organic layer was separated
3. 3
   농축concentrated under a reduced pressure
4. 4
   기타The resulting residue was purified by flash chromatography

실험 절차

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

출처