반응 #47817

반응 방정식

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester

p-toluenesulfonic acid

→

titled compound

수율 62.1%

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

수율 62.1%

용매

methanol

반응 조건

후처리

1. 1
   온도refluxed for 24 hrs
2. 2
   세척The resulting mixture washed with sodium bicarbonate
3. 3
   추출extracted with ethyl acetate
4. 4
   기타The organic layer was separated
5. 5
   건조dried over anhydrous MgSO4
6. 6
   농축concentrated under a reduced pressure
7. 7
   기타Then, the resulting residue was purified by flash chromatography

실험 절차

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester (2 g, 4.85 mmol) obtained in Example 7 was dissolved in methanol, p-toluenesulfonic acid (92 mg, 0.49 mmol) was added thereto, and refluxed for 24 hrs. The resulting mixture washed with sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 1.2 g of the titled compound (yield: 62%).

출처