반응 #47810

반응 방정식

6-(2-Morpholine-4-ylethoxy)-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

6-(2-morpholine-4-ylethoxy)-1-oxo-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

phenylmagnesium chloride

→

titled compound

수율 44.1%

1-hydroxy-6-(2-morpholine-4-yl-ethoxy)-1,3-diphenyl-1H-indene-2-carboxylic Acid Ethyl Ester

수율 44.1%

용매

THF

반응 조건

후처리

1. 1
   세척The resulting mixture washed with saturated saline
2. 2
   추출extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   건조dried over anhydrous MgSO4
5. 5
   농축concentrated under a reduced pressure
6. 6
   기타The resulting residue was purified by flash chromatography

실험 절차

6-(2-Morpholine-4-ylethoxy)-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.5 g, 3.68 mmol) obtained in Step 1 was dissolved in THF, and phenylmagnesium chloride (3.865 mL, 5.89 mmol) was added thereto, followed by stirring for 2 hrs at 0° C. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 788 mg of the titled compound (yield: 44%).

출처