반응 #47808

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1-Oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic acid ethyl ester

1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

phenylmagnesium chloride

→

titled compound

수율 113.9%

1-hydroxy-1,3-diphenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

수율 113.9%

용매

THF

반응 조건

후처리

1. 1
   세척The resulting mixture washed with saturated saline
2. 2
   추출extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   건조dried over anhydrous MgSO4
5. 5
   농축concentrated under a reduced pressure
6. 6
   기타The resulting residue was purified by flash chromatography

실험 절차

1-Oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic acid ethyl ester (350 mg, 0.85 mmol) obtained in Step 1 was dissolved in THF, and phenylmagnesium chloride (0.064 mL, 0.93 mmol) was added thereto, followed by stirring for 1 hr at 0° C. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 475 mg of the titled compound (yield: 100%).

출처