반응 #47802

반응 방정식

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

3-methoxyphenylmagnesium bromide

→

titled compound

수율 90.4%

1-hydroxy-6-methoxy-1-(3-methoxy-phenyl)-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

수율 90.4%

용매

THF

반응 조건

후처리

1. 1
   세척Then, the reaction mixture washed with saturated saline
2. 2
   추출extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   건조dried over anhydrous MgSO4
5. 5
   농축concentrated under a reduced pressure
6. 6
   기타The resulting residue was purified by flash chromatography

실험 절차

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.325 mmol) obtained in Example 1 was dissolved in THF and 1.5 equivalents of 3-methoxyphenylmagnesium bromide were added thereto, followed by stirring for 1 hr at 0° C. Then, the reaction mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 122 mg of the titled compound (yield: 90.4%).

출처