반응 #477205

반응 방정식

Potassium carbonate

t-butyl-3-amino-6-benzyl-4,5,6,7-tetrahydro-7-oxapyrazolo[3,4-c]pyridin-1-carboxylate

3-chloro-1-{4-(2,4-dimethylphenyl)piperazin-1-yl}propan-1-one

→

compound

수율 11.6%

3-amino-1-[{4-(2,4-dimethylphenyl)piperazin-1-yl}propanoyl]-6-N-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one

수율 11.6%

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.ADDITIONAfter adding
2. 2
   workup.WAITwas carried out overnight

실험 절차

Potassium carbonate (68.2 mg, 0.494 mmol) was added to a solution of t-butyl-3-amino-6-benzyl-4,5,6,7-tetrahydro-7-oxapyrazolo[3,4-c]pyridin-1-carboxylate (154 mg, 0.449 mmol) dissolved in anhydrous acetonitrile (1.9 mL) and then stirred at room temperature for 30 minutes. After adding 3-chloro-1-{4-(2,4-dimethylphenyl)piperazin-1-yl}propan-1-one (132.2 mg, 0.471 mmol), reaction was carried out overnight. A target compound (25.4 mg, 0.052 mmol, 11.6%) was yielded as white solid.

출처