반응 #477191

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1-(4-cyclohexylphenyl)piperazine

3-chloropropionyl chloride

→

3-chloro-1-(4-(4-cyclohexylphenyl)piperazin-1-yl)propan-1-one

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후처리

1. 1
   기타purifying by separation through column chromatography (EtOAc:hexane:CH2Cl2, 1:1:5)

실험 절차

A target compound (2.2 g, 6.569 mmol) was yielded as white solid in the same manner as Reference Example 13 by reacting 1-(4-cyclohexylphenyl)piperazine (2.01 g, 8.224 mmol) with 3-chloropropionyl chloride (0.79 mL, 8.224 mmol) and purifying by separation through column chromatography (EtOAc:hexane:CH2Cl2, 1:1:5).

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