반응 #477020

ord-2c4161ef867a4cf4a9cfaee7a1d65950

반응 방정식

O=C([O-])CCCO
4-hydroxybutyrate
O=C([O-])CCO
3-hydroxypropionate
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O
ampicillin
O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
chloramphenicol
O=C([O-])CCCO
4-HB
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O
ampicillin
O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
chloramphenicol
COC(=O)CCCO
methyl-4-hydroxybutyrate
COC(=O)C(C)O
methyl-lactate
CC(O)C(=O)[O-].O=C([O-])CCCO.O=C([O-])CCO
4-Hydroxybutyrate 3-hydroxypropionate lactate
COC(=O)CCO
methyl-3-hydroxypropionate

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

4-Hydroxybutyrate-3-hydroxypropionate-lactate terpolymer was prepared according to the method of example 2 except that the collected cells was anaerobically cultured for 3 days in MR medium further containing 2 g/L of 4-hydroxybutyrate (4-HB), 2 g/L of 3-hydroxypropionate (3-HP), 100 mg/L of ampicillin and 30 mg/L of chloramphenicol instead of MR medium further containing g/L of 4-HB, 100 mg/L of ampicillin and 30 mg/L of chloramphenicol. —As a result of the analysis, methyl-4-hydroxybutyrate, methyl-3-hydroxypropionate and methyl-lactate were detected in E. coli Top10/pPs619C1300-CPPCT/pMCSPtbBuk transformant, which meant that new 4-hydroxybutyrate-3-hydroxypropionate-lactate terpolymer [poly(4-hydroxybutyrate-co-3-hydroxypropionate-co-lactate)] was prepared by the recombinant E. Coli. 1H-NMR and GC-MSD results of the obtained 4-hydroxybutyrate-3-hydroxypropionate-lactate terpolymer were shown in FIGS. 6 and 7, respectively.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08383379B2uspto-grants-2013_02