반응 #476971

반응 방정식

L(+)-arginine

water

hydrochloric acid

2-ethylhexyl glycidyl ether

→

N-[2-hydroxy-3-(2-ethylhexyl)oxypropyl]-L-arginine hydrochloride

용매

ethanol

반응 조건

후처리

1. 1
   기타In a four-necked 200-mL flask equipped with a reflux
2. 2
   온도cooling tube, a dropping funnel
3. 3
   온도Subsequently, the inside of the reaction system was maintained at 78 to 80° C.
4. 4
   기타was returned to room temperature
5. 5
   workup.DISTILLATIONWater and ethanol were completely distilled off from the reaction solution under reduced pressure

실험 절차

In a four-necked 200-mL flask equipped with a reflux cooling tube, a dropping funnel, a thermometer and a stirring blade, 9.4 g (53.7 mmol) of L(+)-arginine, 50.0 g of water and 50.0 g of ethanol were placed, and the mixture was heated to 78° C. while being stirred under a nitrogen atmosphere. Subsequently, the inside of the reaction system was maintained at 78 to 80° C., 10.0 g (53.7 mmol) of 2-ethylhexyl glycidyl ether was added dropwise thereto. Thereafter, the mixture was aged for 4 hours at 78 to 80° C., and then was returned to room temperature. Subsequently, 9.8 g (53.7 mmol) of a 6 mol/L aqueous solution of hydrochloric acid was added thereto to neutralize the mixture. Water and ethanol were completely distilled off from the reaction solution under reduced pressure, and thus 21.6 g of N-[2-hydroxy-3-(2-ethylhexyl)oxypropyl]-L-arginine hydrochloride was obtained as a white solid. This compound corresponds to the compound 2 of Table 1.

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