반응 #47653

반응 방정식

(S)-2-{4-[3-(2-hydroxy-2-methyl-propyl)-phenoxy]-2-oxo-2,5-dihydro-pyrrol-1-yl}-4-methyl-pentanoic acid

1-methyl-1H-pyrazol-3-ylamine

N,N-diisopropylethylamine

benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate

→

(S)-2-{4-[3-(2-hydroxy-2-methyl-propyl)-phenoxy]-2-oxo-2,5-dihydro-pyrrol-1-yl}-4-methyl-pentanoic acid (1-methyl-1H-pyrazol-3-yl)-amide

수율 62.0%

용매

water

ethyl acetate

dichloromethane

반응 조건

후처리

1. 1
   기타The organic layer was then collected
2. 2
   농축concentrated in vacuo
3. 3
   기타The residue was purified by flash column chromatography (silica gel 30% to 100% ethyl acetate/hexanes) which

실험 절차

To a solution of (S)-2-{4-[3-(2-hydroxy-2-methyl-propyl)-phenoxy]-2-oxo-2,5-dihydro-pyrrol-1-yl}-4-methyl-pentanoic acid (0.100 g, 0.28 mmol) in dichloromethane (10 mL) was added 1-methyl-1H-pyrazol-3-ylamine (0.040 g, 0.41 mmol), N,N-diisopropylethylamine (0.110 g, 0.85 mmol) and benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate (0.180 g, 0.41 mmol) at 0° C. The mixture was allowed to slowly warm up to room temperature and then stirred for 2 h. The mixture was partioned between ethyl acetate and water. The organic layer was then collected and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel 30% to 100% ethyl acetate/hexanes) which afforded (S)-2-{4-[3-(2-hydroxy-2-methyl-propyl)-phenoxy]-2-oxo-2,5-dihydro-pyrrol-1-yl}-4-methyl-pentanoic acid (1-methyl-1H-pyrazol-3-yl)-amide (0.075 g, 62%) as a white solid: HR-ES-MS m/z calculated for C24H32N4O4 [M+H]+ 441.2497, observed 441.2497; 1H NMR (300 MHz, CDCl3) δ ppm 0.92-1.01 (m, 6H), 1.24 (s, 6H), 1.40-1.69 (m, 2H), 1.68-1.97 (m, 2H), 2.78 (s, 2H), 3.82 (br. s., 3H), 4.07 (d, J=18.1 Hz, 1H), 4.27 (d, J=17.5 Hz, 1H), 4.79-4.94 (m, 1H), 4.97 (s, 1H), 6.60 (br. s., 1H), 7.07 (br. s., 2H), 7.14 (d, J=7.5 Hz, 1H), 7.30-7.40 (m, 2H), 8.55 (br. s., 1H).

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