반응 #475361

ord-f2c0b9f44e33455e90132b83c01431cd

반응 방정식

COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314.O=C(O)C(O)C(O)C(=O)O
hydrocodone bitartrate
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
Hydrocodone

반응물

—
ion-exchange
COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314.O=C(O)C(O)C(O)C(=O)O
hydrocodone bitartrate

시약

없음

용매

O
water

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    세척the product washed with USP water
  2. 2
    기타The wet cake was dried
  3. 3
    여과sieved through a US Std #30 mesh screen

실험 절차

Hydrocodone polistirex was prepared by mixing 4.00 kg of hydrocodone bitartrate with 4.76 kg of ion-exchange resin particles (ABMERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 70° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The hydrocodone content of the dried product was equivalent to approximately 56% by weight of hydrocodone bitartrate.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08377480B2uspto-grants-2013_02