반응 #474544

반응 방정식

5-bromo-3-(1,1-dioxidotetrahydro-3-thienyl)-1H-indole-7-carboxamide

2-furanylboronic acid

Potassium carbonate

→

title compound

수율 36.0%

3-(1,1-Dioxidotetrahydro-3-thienyl)-5-(2-furanyl)-1H-indole-7-carboxamide

수율 36.0%

용매

1,4 dioxane water

반응 조건

후처리

1. 1
   기타the solution was degassed with Argon
2. 2
   기타to remove palladium
3. 3
   기타purified on Gilson preparative HPLC
4. 4
   농축The desired fractions were concentrated

실험 절차

5-bromo-3-(1,1-dioxidotetrahydro-3-thienyl)-1H-indole-7-carboxamide (0.050 g, 0.140 mmol) and 2-furanylboronic acid (0.020 g, 0.182 mmol) was dissolved in a 6:1 solution of 1,4 dioxane/water in a 20 mL microwave reaction vessel. Potassium carbonate (0.097, 0.70 mmol) was added and the solution was degassed with Argon. PdCl2(dppf) (0.017 g, 0.024 mmol) was added and the reaction was heated in a microwave at 100° C. for 10 min. The solution was passed through a StratoSphere SPE PL-Thiol MP SPE column to remove palladium and purified on Gilson preparative HPLC using Acetonitrile/0.1% NH4OH/H20. The desired fractions were concentrated, giving 0.017 g (36%) of the title compound.

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