반응 #474453

반응 방정식

5-bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-1H-indole-7-carboxylic acid

EDC

HOBt

ammonia

1,4-dioxane

→

title compound

수율 87.3%

5-Bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-1H-indole-7-carboxamide

수율 87.3%

용매

water

DMF

반응 조건

후처리

1. 1
   기타Reaction
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The combined organics were washed with 1N NaOH, water, and brine
4. 4
   건조then dried with magnesium sulfate

실험 절차

5-bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-1H-indole-7-carboxylic acid (0.185 g, 0.497 mmol) was suspended in DMF (2 mL) with EDC (0.286 g, 1.49 mmol, 3 eq) and HOBt (0.076, 0.497 mmol) in a 10 mL microwave reaction vessel. 0.5M ammonia in 1,4-dioxane (1.9 mL, 0.9945 mmol, 2 eq) was added and heated on the microwave at 100° C. for 20 minutes. Reaction was diluted with water and extracted with ethyl acetate. The combined organics were washed with 1N NaOH, water, and brine then dried with magnesium sulfate, to give 0.161 g (87%) of the title compound.

출처