반응 #474436

반응 방정식

1-(1,1-dimethylethyl) 7-methyl 5-bromo-3-(1,1-dioxidotetrahydro-3-thienyl)-1H-indole-1,7-dicarboxylate

LiOH

MeOH

→

title compound

수율 30.4%

5-bromo-3-(1,1-dioxidotetrahydro-3-thienyl)-1H-indole-7-carboxylic acid

수율 30.4%

용매

H2O

반응 조건

후처리

1. 1
   기타The reaction mixture was then purified via Gilson HPLC (TFA buffer)

실험 절차

To a microwave vial was added 1-(1,1-dimethylethyl) 7-methyl 5-bromo-3-(1,1-dioxidotetrahydro-3-thienyl)-1H-indole-1,7-dicarboxylate (432 mg, 0.91 mmol), LiOH (109 mg, 4.5 mmol), MeOH (6 mL) and H2O (3 mL). The mixture was heated to 80° C. for 30 min in the microwave. The reaction mixture was then purified via Gilson HPLC (TFA buffer) to give 99 mg of the title compound.

출처