반응 #4744

반응 방정식

ammonia

3-hydroxybenzaldehyde

3-methylpiperidine

formic acid

→

3-[(3-Methylpiperidin-1-yl)methyl]phenol

용매

water

반응 조건

후처리

1. 1
   온도with cooling
2. 2
   온도When the reaction mixture has cooled to room temperature
3. 3
   여과the precipitated solid is filtered off
4. 4
   기타recrystallised from ethanol

실험 절차

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

출처