반응 #4742

반응 방정식

N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

ammonia

→

(±)-N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

용매

phosphorus oxychloride

반응 조건

후처리

1. 1
   온도When cooled
2. 2
   온도with cooling
3. 3
   추출The product is extracted with ether
4. 4
   세척the combined ether extracts are washed
5. 5
   농축concentrated by evaporation
6. 6
   기타The solid residue is recrystallised from ether

실험 절차

7 mmol of N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide in 30 ml of phosphorus oxychloride are stirred for 6 hours at 50°-60° C. When cooled, the reaction mixture is poured out on 300 ml of ice water and neutralized by the addition of concentrated ammonia solution with cooling. The product is extracted with ether and the combined ether extracts are washed, dehydrated and concentrated by evaporation. The solid residue is recrystallised from ether.

출처