반응 #474108

반응 방정식

Naproxen

→

2-(6-Hydroxy-naphthalen-2-yl)-propionic acid

용매

HBr

반응 조건

후처리

1. 1
   온도was refluxed for 10 Hours
2. 2
   workup.ADDITIONpoured onto ice water (3000 ml)
3. 3
   여과Crude 36 was filtered
4. 4
   기타dried (380 grams, 81%)

실험 절차

A mixture of Naproxen (500 grams, 2.774 mmol) and 48% HBr (1500 ml) was refluxed for 10 Hours, poured onto ice water (3000 ml) and stirred for 30 minutes. Crude 36 was filtered, dried (380 grams, 81%) and used as such for next stage.

출처