반응 #4733

반응 방정식

5-bromo-1,3,4-thiadiazole-2-amine

triethylamine

1-amino-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol

→

1-[(5-Amino-1,3,4-thiadiazol-2-yl)amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol

용매

THF

반응 조건

후처리

1. 1
   기타the mixture is reacted in a manner analogous to Example 51
2. 2
   기타The oil obtained
3. 3
   기타is purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95))

실험 절차

0.54 g (3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amine and 0.45 ml of triethylamine are added to 0.8 g (3 mmol) of 1-amino-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol in 20 ml of THF and the mixture is reacted in a manner analogous to Example 51. The oil obtained is purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95)).

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