반응 #4732

반응 방정식

4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine

triethylamine

5-bromo-1,3,4-thiadiazole-2-amin

→

N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine

용매

THF

반응 조건

후처리

1. 1
   여과Solid triethylammonium bromide is filtered off
2. 2
   농축the filtrate is concentrated by evaporation
3. 3
   기타the oily residue is purified by preparative layer chromatography

실험 절차

0.6 g (2.3 mmol) of 4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine, 0.35 ml of triethylamine and 0.42 g (2.3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amin are heated under reflux in 20 ml of THF for 3 hours. Solid triethylammonium bromide is filtered off, the filtrate is concentrated by evaporation and the oily residue is purified by preparative layer chromatography.

출처