반응 #472300

반응 방정식

4-benzyloxy-3-chloro-5-methoxybenzoic acid

toluene

thionyl chloride

→

title compound

4-benzyloxy-3-chloro-5-methoxybenzoyl chloride

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
2. 2
   기타azeotroped with toluene

실험 절차

To 4-benzyloxy-3-chloro-5-methoxybenzoic acid (541 mg), toluene (5.4 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (578 mg) as a yellow solid.

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