반응 #4722

반응 방정식

triethylamine

phenyl isocyanide dichloride

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide

→

N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

용매

THF

반응 조건

후처리

1. 1
   여과Solid triethylammonium chloride is filtered off
2. 2
   농축the filtrate is concentrated by evaporation under vacuum
3. 3
   기타the solid residue is recrystallised from ethanol

실험 절차

1.4 ml (10 mmol) of triethylamine and 0.7 ml (5 mmol) of phenyl isocyanide dichloride are added to 1.5 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide in 30 ml of THF and the mixture is stirred at room temperature until the reaction is quantitative. Solid triethylammonium chloride is filtered off, the filtrate is concentrated by evaporation under vacuum, and the solid residue is recrystallised from ethanol. The analytical values are summarized in Table II.

출처