반응 #47199

반응 방정식

MeOH

methyl 5-tert-butyl-3-nitrothiophene-2-carboxylate

THF

HCl

→

5-tert-butyl-3-nitrothiophene-2-carboxylic acid

수율 96.6%

용매

water

반응 조건

후처리

1. 1
   온도The reaction was cooled down to room temperature
2. 2
   추출extracted with ethyl acetate
3. 3
   기타the crude product was recrystallized from dichloromethane

실험 절차

LiOH monohydrate (0.122 g, 2.90 mmol) was dissolved in 1 mL water and added to methyl 5-tert-butyl-3-nitrothiophene-2-carboxylate (0.235 g, 0.966 mmol) in 3 ml of a 3:1 mixture of THF:MeOH. The resulting mixture was heated at 75° C. for 5 hours. The reaction was cooled down to room temperature, acidified with 1N HCl, extracted with ethyl acetate, and the crude product was recrystallized from dichloromethane:hexane to afford 0.214 g of 5-tert-butyl-3-nitrothiophene-2-carboxylic acid as a yellow solid.

출처