반응 #47181

반응 방정식

cinnamyl alcohol

DDQ

→

Methyl cinnamate

수율 86.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타is taken in a round bottom flask
2. 2
   기타After completion of the reaction (observed by TLC and by GC analysis)
3. 3
   여과the reaction mixture is filtered
4. 4
   세척washed with MeOH (5 ml×2)
5. 5
   농축Concentrate the filtrate under reduced pressure
6. 6
   기타the crude product thus obtained
7. 7
   세척eluted with diethyl ether

실험 절차

A homogeneous mixture containing cinnamyl alcohol (7.5 mmol), DDQ (22.5 mmol), MeOH (20 mL) is taken in a round bottom flask and catalytic amount of AMBERLYST® 15 (0.1 g) is added to it. The mixture is stirred for 20 hrs at room temperature. After completion of the reaction (observed by TLC and by GC analysis), the reaction mixture is filtered and washed with MeOH (5 ml×2). Concentrate the filtrate under reduced pressure and the crude product thus obtained is loaded on a neutral alumina column and eluted with diethyl ether. Methyl cinnamate is isolated in 86% yield whose NMR values are found matching with reported values as in example 1.

출처