반응 #471781

반응 방정식

hydrochloric acid

6-(4-methoxy-benzoyl)-7-oxa-bicyclo[4.2.0]octan-8-one

diethanolamine

N,N-diisopropylethylamine

→

title compound

2-Hydroxy-2-(4-methoxy-benzoyl)cyclohexanecarboxylic acid bis(2-hydroxyethyl)amide

용매

methylene chloride

반응 조건

후처리

1. 1
   온도The reaction mixture is heated
2. 2
   온도at reflux for several hours
3. 3
   기타Upon completion of the reaction
4. 4
   온도the mixture is cooled
5. 5
   세척The organic layer is washed with water
6. 6
   건조dried over anhydrous sodium sulfate
7. 7
   농축concentrated

실험 절차

A solution of 26.03 g (0.100 mol) of 6-(4-methoxy-benzoyl)-7-oxa-bicyclo[4.2.0]octan-8-one in 200 ml of methylene chloride is added to 10.5 g (0.100 mol) of diethanolamine and 32 ml of N,N-diisopropylethylamine. The reaction mixture is heated at reflux for several hours and monitored by thin layer chromatography. Upon completion of the reaction, the mixture is cooled and poured into 1N hydrochloric acid solution. The organic layer is washed with water, dried over anhydrous sodium sulfate, and concentrated to give the title compound.

출처