반응 #47146

반응 방정식

HCl

4-chloroaniline

pivaloyl chloride

→

title compound

N-(4-Chloro-phenyl)-2,2-dimethyl-propionamide

용매

pyridine

반응 조건

후처리

1. 1
   workup.ADDITIONThe mixture was poured
2. 2
   여과the solids were collected by vacuum filtration
3. 3
   세척washed well with H2O
4. 4
   기타dried in vacuo

실험 절차

To a solution of 4-chloroaniline (5.0 g, 39.2 mmol) in 25 mL pyridine was added 5.3 mL (43.1 mmol) of pivaloyl chloride and the reaction mixture stirred overnight at room temperature. The mixture was poured into vigorously stirring 6M HCl, and the solids were collected by vacuum filtration, washed well with H2O, and dried in vacuo to yield the title compound. 1H NMR (CDCl3) δ 7.47 (d, J=9.2 Hz, 2H) 7.30 (s, 1H) 7.27 (d, J=8.8 Hz, 2H) 1.32 (s, 9H) MS (ES) m/z=212.1

출처