반응 #47116

반응 방정식

Hydrogen chloride

1-phenyl-2-(pyridin-3-yl)ethan-1,2-dione

sulfamide

→

product 497

3-(Pyridin-3-yl)-4-phenyl-1,2,5-thiadiazole-1,1-dioxide hydrochloride

용매

methanol

반응 조건

후처리

1. 1
   온도to reflux
2. 2
   온도then cooled to rt
3. 3
   기타The solid that formed
4. 4
   여과is filtered
5. 5
   기타dried

실험 절차

Hydrogen chloride gas is bubbled into a solution of 1-phenyl-2-(pyridin-3-yl)ethan-1,2-dione (1.63 g, 7.7 mmol, J. Org. Chem., 1999, 64, 6102) and sulfamide (750 mg, 7.7 mmol) in methanol (10 mL) until the solution begins to reflux. The gas flow is turned off, and the solution stirred at 65° C. for 3 h then cooled to rt. The solid that formed is filtered and dried to give 2.06 g of the product 497. MS: m/z 272 (M++1).

출처