반응 #47098

반응 방정식

2-phenoxyethan-1-ol

ethyl diazoacetate

→

product 440

수율 82.8%

(2-Phenoxy)ethoxyacetic acid ethyl ester

수율 82.8%

용매

heptane

dichloromethane

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타The filtrate is evaporated
3. 3
   workup.DISTILLATIONthe residue vacuum distilled

실험 절차

To a solution of 2-phenoxyethan-1-ol (1.5 mL, 12.7 mmol) in dichloromethane (50 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (1.1 mL, 10.5 mmol). The reaction mixture is stirred at rt overnight. The reaction mixture is diluted with heptane, and filtered. The filtrate is evaporated, and the residue vacuum distilled to give 1.95 g of the product 440. 1H NMR (CDCl3) δ 7.40-7.25 (m, 2 H), 7.10-6.90 (m, 3 H), 4.30-4.15 (m, 5 H), 4.15-4.05 (m, 1 H), 4.05-3.90 (s, 2 H), 1.28 (t, 3 H)

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