반응 #47088

반응 방정식

cyclohexanol

ethyl diazoacetate

→

product 407

Cyclohexyloxyacetic acid ethyl ester

용매

Et2O

dichloromethane

반응 조건

후처리

1. 1
   여과filtered through Celite
2. 2
   기타the filtrate is evaporated
3. 3
   workup.DISTILLATIONdistilled at 150° C.

실험 절차

To a solution of cyclohexanol (1.0 g, 0.95 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (44 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is diluted with Et2O, filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 150° C. to give 1.57 g of the product 407. 1H NMR (CDCl3) δ 4.23 (q, 2H), 4.10 (s, 2H), 3.33 (m, 1H), 1.93 (m, 2H), 1.74 (m, 2H), 1.54 (m, 1H), 1.4-1.1 (m, 8H)

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