반응 #47085

반응 방정식

Et2O

thiophenol

potassium carbonate

ethyl bromoacetate

→

product 400

수율 89.8%

(Phenylthio)acetic acid ethyl ester

수율 89.8%

용매

DMF

반응 조건

후처리

1. 1
   세척the mixture is washed with water, brine
2. 2
   건조dried (MgSO4)
3. 3
   여과filtered
4. 4
   기타The filtrate is evaporated
5. 5
   workup.DISTILLATIONdistilled (130-140° C.)

실험 절차

To a solution of thiophenol (1 mL, 9.7 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.71 g of the product 400. 1H NMR (CDCl3) δ 7.41 (d, 2H), 7.33-7.2 (m, 4H), 4.16 (q, 2H), 3.63 (s, 2H), 1.22 (t, 3H); MS: m/z 196 (M++1).

출처