반응 #47080

반응 방정식

benzyl alcohol

ethyl diazoacetate

→

product 390

수율 93.2%

Benzyloxyacetic acid ethyl ester

수율 93.2%

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.DISTILLATIONdistilled at 110° C.

실험 절차

To a solution of benzyl alcohol (1.04 mL, 10.0 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (40 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is rotary evaporated, and the residue is vacuum distilled at 110° C. to give 1.81 g of the product 390. 1H NMR (CDCl3) δ 7.4-7.26 (m, 5H), 4.65 (s, 2H), 4.23 (q, 2H), 4.10 (s, 2H), 1.30 (t, 3H).

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