반응 #47077

반응 방정식

chloroacetonitrile

2-fluorophenol

potassium carbonate

→

product 384

수율 97.4%

(2-Fluorophenoxy)acetonitrile

수율 97.4%

용매

EtOAc

DMF

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled to RT
2. 2
   세척washed with water, brine
3. 3
   건조dried (MgSO4)
4. 4
   여과filtered
5. 5
   기타The filtrate is evaporated
6. 6
   기타the residue purified by chromatography on silica gel
7. 7
   세척elution with dichloromethane

실험 절차

To a solution of 2-fluorophenol (560 mg, 5.0 mmol) in DMF (10 mL) is added potassium carbonate (828 mg, 6.0 mmol) followed by chloroacetonitrile (0.315 mL, 50.0 mmol). The reaction mixture is stirred and heated at 50° C. for 14 h. The reaction mixture is cooled to RT, diluted with EtOAc, and washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue purified by chromatography on silica gel; elution with dichloromethane gives 736 mg of the product 384.

출처