반응 #47057

반응 방정식

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

4-trifluoromethylbenzyl chloride

→

product 228

수율 74.3%

2-[(4-Trifluoromethylbenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

수율 74.3%

용매

EtOH

반응 조건

후처리

1. 1
   기타evaporated to dryness
2. 2
   여과The insoluble material is filtered

실험 절차

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-trifluoromethylbenzyl chloride (0.232 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 262 mg of the product 228. 1H NMR (DMSO-d6) δ 11.42 (s, 2 H), 7.95-7.90 (m, 4 H), 7.15-6.90 (m, 6 H), 6.90-6.65 (m, 4 H), 5.77 (s, 2 H), 4.92 (s, 2 H); MS: m/z 413 (M++1).

출처