반응 #470429

반응 방정식

4-formylbenzoic acid

2-fluoroaniline

decaborane

→

47c

수율 99.2%

4-(((2-fluorophenyl)amino)methyl)benzoic acid

수율 99.2%

용매

MeOH

반응 조건

후처리

1. 1
   농축The mixture was concentrated
2. 2
   기타purified by preparative reverse-phase chromatography

실험 절차

A mixture of 4-formylbenzoic acid 47a (3.33 mmol, 500 mg), 2-fluoroaniline 47b (3.33 mmol, 370 mg), and decaborane (1 mmol, 122 mg) in 8 mL of MeOH was stirred at room temperature for 15 min. The mixture was concentrated and purified by preparative reverse-phase chromatography to afford 0.81 g (99%) of 47c.

출처