반응 #470416

반응 방정식

water

Benzylamine

3′,7-Dihydroxyisoflav-3-ene

ethanol

formaldehyde

→

title compound

3-(3-Benzyl-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol

반응 조건

후처리

1. 1
   기타Reaction mixture
2. 2
   추출then extracted with ethyl acetate (3×30 ml)
3. 3
   기타chromatographed

실험 절차

3′,7-Dihydroxyisoflav-3-ene (100 mg, 0.42 mmol) was dissolved in ethanol (4 ml). Benzylamine (0.14 ml, 1.28 mmol) was added followed by formaldehyde solution (0.42 ml, 5.59 mmol, 37% wt.). The reaction was stirred at room temperature for 1 day. Reaction mixture was poured into water (50 ml) then extracted with ethyl acetate (3×30 ml) and the combined organic layers reduced. The solid was flash chromatographed using 100% dichloromethane. Fractions 6-12 were combined and reduced to afford the title compound.

출처