반응 #470392

반응 방정식

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

수율 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

수율 47.9%

용매

water

반응 조건

후처리

1. 1
   온도After cooled to room temperature
2. 2
   추출The mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   기타The solvent was evaporated
4. 4
   기타the residue was purified by column chromatography

실험 절차

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

출처