반응 #470391

반응 방정식

2-phenyl-1H-benzo[d]imidazole

ethanol

→

desired product

1-(2-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole

반응 조건

후처리

1. 1
   온도The mixture was heated up
2. 2
   온도to reflux for 24 hours
3. 3
   여과the precipitate was collected by filtration
4. 4
   기타The product was purified by column chromatography

실험 절차

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

출처