반응 #470378

반응 방정식

Methylchloroformate

maleimide

NMM

→

product

수율 55.0%

N-(Methoxycarbonyl)maleimide

수율 55.0%

용매

EtOAc

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척washed with EtOAc
3. 3
   세척washed with cold water
4. 4
   건조dried over anhydrous Na2SO4
5. 5
   여과After filtration and evaporation under vacuum a pink solid
6. 6
   기타was obtained
7. 7
   기타Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1

실험 절차

Methylchloroformate (4.4 mL, 56.7 mmol, 1 eq) was added to a solution of maleimide (5.5 g, 56.7 mmol, 1 eq) and NMM (6.2 mL, 56.7 mmol, 1 eq) in 200 mL of EtOAc at 0° C. The suspension was stirred at 0° C. for 30 minutes, filtered and washed with EtOAc. Filtrate and washings were combined and washed with cold water and dried over anhydrous Na2SO4. After filtration and evaporation under vacuum a pink solid was obtained. Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1, v/v) provided the product (4.8 g, 55%).

출처