반응 #470363

반응 방정식

N-methylpyrrolidine

bromomethyl methyl ether

→

desired product

N-Methoxymethyl-N-Methylpyrrolidinium Bromide

용매

acetone

water

반응 조건

후처리

1. 1
   기타to terminate
2. 2
   기타the reaction
3. 3
   여과The reaction mixture was filtered
4. 4
   세척the resulting solids were washed with 160 g of acetone
5. 5
   기타dried in a vacuum

실험 절차

A 17.0 g quantity of N-methylpyrrolidine was dissolved in 160 g of dehydrated acetone (up to 0.1% in water content), followed by nitrogen replacement. To the solution was added dropwise 24.6 g of bromomethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd.) at 5° C. over a period of 1.5 hours. The mixture was stirred at 5 to not higher than 15° C. for 4 hours to terminate the reaction. The reaction mixture was filtered, and the resulting solids were washed with 160 g of acetone, and dried in a vacuum, affording 30.9 g of the desired product (white solid).

출처