반응 #4701

반응 방정식

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methyl isothiocyanate

Ether

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide

용매

THF

반응 조건

후처리

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   기타the precipitate formed
3. 3
   여과filtered
4. 4
   세척washed with ether
5. 5
   기타recrystallised from ethanol

실험 절차

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

출처