반응 #46989

반응 방정식

Hydrogen chloride

3,3′-difluorobenzil

3,3′-Difluorobenzil

sulfamide

→

product 21

수율 72.8%

3,4-bis-(3-Fluorophenyl)-1,2,5-thiadiazole-1,1-dioxide

수율 72.8%

용매

methanol

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled to RT
2. 2
   기타the solvent rotary evaporated, and the residue triturated from heptane

실험 절차

Hydrogen chloride is bubbled through a solution of 3,3′-difluorobenzil (20) (3.81 g, 15.7 mmol) and sulfamide (1.53 g, 15.9 mmol) in methanol (15 mL) for 0.5 min followed by heating at 66° C. for 2 h. The reaction mixture is cooled to RT, the solvent rotary evaporated, and the residue triturated from heptane to give 3.50 g of the product 21.

출처