반응 #469840

반응 방정식

4-piperidone monohydrate hydrochloride

AlCl3

benzene

water

→

off-white solid

수율 72.0%

4,4-Diphenylpiperidine hydrochloride

수율 72.0%

반응 조건

후처리

1. 1
   온도at reflux for 4 hours
2. 2
   여과filtered
3. 3
   세척The solid was washed with toluene
4. 4
   기타dried

실험 절차

A mixture of 4-piperidone monohydrate hydrochloride (15.0 g, 97.6 mmol, 1.00 equiv) and AlCl3 (130 g, 976 mmol, 10.0 equiv) in anhydrous benzene (600 mL) was stirred at reflux for 4 hours. The mixture was cooled to room temperature, poured into ice (300 g) and water (50 mL), and filtered. The solid was washed with toluene and dried to afford 19.2 g (72%) of off-white solid, which was characterized spectroscopically.

출처