반응 #46975

반응 방정식

18

5-Bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-yl amine

AIBN

Bu3SnH

→

compound 19

수율 90.0%

1-(4-Methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine

수율 90.0%

용매

toluene

반응 조건

후처리

1. 1
   온도to reflux for 15 h
2. 2
   온도After cooling
3. 3
   기타the reaction mixture was evaporated
4. 4
   추출extracted by CH2Cl2
5. 5
   건조The combined organic layer was dried by MgSO4
6. 6
   농축concentrated
7. 7
   기타to give a residue that
8. 8
   기타was purified by silica gel flash column chromatography (EtOAc:n-hexane=1:2)

실험 절차

To a stirred solution of 18 (2 g, 4.84 mmol), AIBN (0.08 g, 0.48 mmol), Bu3SnH (3.91 ml, 14.50 mmol) in toluene (49 ml) was heated to reflux for 15 h. After cooling, the reaction mixture was evaporated and then extracted by CH2Cl2. The combined organic layer was dried by MgSO4 and concentrated to give a residue that was purified by silica gel flash column chromatography (EtOAc:n-hexane=1:2) to give compound 19, yield 90%.

출처