반응 #46973

반응 방정식

5-bromo-7-nitroindoline

4-methoxyphenylsulfonyl chloride

→

compound 17

수율 85.0%

5-Bromo-1-(4-methoxy-benzenesulfonyl)-7-nitro-2,3-dihydro-1H-indole

수율 85.0%

용매

pyridine

반응 조건

후처리

1. 1
   기타The reaction was quenched with water
2. 2
   추출extracted with CH2Cl2
3. 3
   건조The combined organic layer was dried over anhydrous MgSO4
4. 4
   기타evaporated
5. 5
   기타to give a residue that
6. 6
   기타was chromatographed over silica gel (EtOAc:n-hexane=1:2)

실험 절차

A solution of 5-bromo-7-nitroindoline (5 g, 0.021 mol), 4-methoxyphenylsulfonyl chloride (6.36 g, 0.030 mol) in pyridine (10 ml) was stirred at 120° C. for 16 h. The reaction was quenched with water and extracted with CH2Cl2. The combined organic layer was dried over anhydrous MgSO4 and evaporated to give a residue that was chromatographed over silica gel (EtOAc:n-hexane=1:2) to afford compound 17, yield 85%.

출처