반응 #46904

반응 방정식

4-hydroxybenzamide

diclofenac

hydroxybenzotriazole

DCC

→

4-carbamoylphenyl 2-[2-(2,6-dichlorophenylamino)-phenyl]acetate

수율 17.0%

용매

chloroform

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGstirred for 1 h at 0° C.
2. 2
   기타at room temperature
3. 3
   여과After filtration
4. 4
   기타the filtrate was evaporated under reduced pressure
5. 5
   기타the oily residue thus obtained
6. 6
   세척the organic layer was washed with brine
7. 7
   건조dried on anhydrous MgSO4
8. 8
   여과filtered
9. 9
   기타the solvent evaporated
10. 10
    세척eluted with CH2Cl2/MeOH (9/1), from which 4-carbamoylphenyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate (5)
11. 11
    기타was obtained (212 mg, 17% yield)

실험 절차

To the solution of 1 (diclofenac, 890 mg, 3.0 mmol) in 50 mL of N,N-dimethylformamide, hydroxybenzotriazole (445 mg, 3.3 mmol) and DCC (680 mg, 3.3 mmol) were added with stirring at 0° C. for 1 h. To the reaction mixture 4-hydroxybenzamide (4, 616 mg, 4.5 mmol) was added and stirred for 1 h at 0° C. and 3 hs at room temperature. After filtration, the filtrate was evaporated under reduced pressure and the oily residue thus obtained was dissolved in chloroform; the organic layer was washed with brine, dried on anhydrous MgSO4, filtered and the solvent evaporated. The crude product 5 was loaded on a silica gel open column and eluted with CH2Cl2/MeOH (9/1), from which 4-carbamoylphenyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate (5) was obtained (212 mg, 17% yield).

출처