반응 #468897

반응 방정식

simvastatin phenylboronate

neopentyl glycol

→

simvastatin

수율 76.0%

용매

toluene

반응 조건

후처리

1. 1
   농축The solution was concentrated under reduced pressure at a bath temperature of 60° C. to a final volume of 5 mL and n-heptane (160 mL)
2. 2
   workup.ADDITIONwas added at a temperature of 50-60° C
3. 3
   여과The crude simvastatin was filtered
4. 4
   세척washed with heptane

실험 절차

A mixture of simvastatin phenylboronate (5.22 g, 0.010 mol), toluene (31 mL), and neopentyl glycol (1.11 g, 0.0107 mol) was heated under a nitrogen atmosphere at 77 to 79° C. for 1 hour and 40 minutes. The solution was concentrated under reduced pressure at a bath temperature of 60° C. to a final volume of 5 mL and n-heptane (160 mL) was added at a temperature of 50-60° C. The crude simvastatin was filtered and washed with heptane to provide 3.17 g (76%) of simvastatin. By appropriate manipulation of the conditions and reagents, compounds such as the compactin analogue of simvastatin may be prepared.

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