반응 #468893

ord-658d7d10b5e145a98d878620a12745a5

반응 방정식

[O-]B[O-]
boronate
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
III
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
Simvastatin boronate
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
III
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
Simvastatin boronate
→
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
simvastatin

반응물

[O-]B[O-]
boronate
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
III
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
Simvastatin boronate
—
diol
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
III
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21.[O-]B[O-]
Simvastatin boronate
—
polyol

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    농축The organic solution is concentrated

실험 절차

Alternatively, III may be dissolved in an organic solvent and recirculated over a supported diol or polyol stationary phase to which the boronate moiety of III becomes attached. The organic solution is concentrated to obtain simvastatin.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06307066B1uspto-grants-2001_10