반응 #4687

반응 방정식

4-Cyano-2(R,S)-α-naphthoxybutyric acid

KOH

α-naphthoxymalonic acid diethyl ester

acrylonitrile

→

(2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester

용매

ethyl acetate

반응 조건

후처리

1. 1
   세척The ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine
2. 2
   건조dried over sodium sulphate
3. 3
   농축concentrated by evaporation

실험 절차

4-Cyano-2(R,S)-α-naphthoxybutyric acid: 0.11 ml of a 50% aqueous KOH solution is added at 0°, while stirring, to a mixture of 5.0 g of α-naphthoxymalonic acid diethyl ester and 1.09 ml of acrylonitrile. The reaction mixture is stirred for 5 days at room temperature and then dissolved in ethyl acetate. The ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine, dried over sodium sulphate and concentrated by evaporation, leaving (2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester.

출처